Endoscopic ultrasonography-guided interstitial chemotherapy in pancreas: a pilot study in canine model

VernacularTitle:超声内镜引导下胰腺组织间化疗的实验研究
Author: Sheng WANG ; Nan GE ; Siyu SUN
Publication Type:Journal Article
Keywords: Pancreas; Endoscopic ultrasonography; Chemotherapy; Fluorouraci
From: Chinese Journal of Digestive Endoscopy 2010;27(2):89-92
CountryChina
Language:Chinese
Abstract: Objective To investigate the feasibility and safety of endoscopic ultrasonography (EUS) guided interstitial chemotherapy for the pancreas in canine model. Methods A therapeutic 19gauge needle was inserted into the pancreas with EUS guidance,and seeds with sustained release of 5-iluorouracil were implanted into the tissue. After 14 days of clinical observation,the animals were sacrificed and the tissue response to local chemotherapy was examined. Results All the seeds were implanted successfuUy and no migration was observed. Chemotherapy induced tissue fibrous necrosis was localized in the pancreas without significant complications. The apoptotic index of tissue within 1 cm of the seeds increased.Biochemical parameters were normal in all the dogs. Conclusion EUS-guided implantation of seeds is a safe,simple and minimally invasive technique for interstitial chemotherapy in the pancreas.