CT guided percutaneous radiofrequency ablation in treatment of patients with inoperable lung cancer

VernacularTitle:CT引导下射频消融治疗肺癌
Author: Xiuyi ZHI ; Baodong LIU ; Weijian FENG
Publication Type:Journal Article
Keywords: Lung neoplasms; Catheter ablation; Minimally invasive procedure
From: Cancer Research and Clinic 2010;22(1):19-22
CountryChina
Language:Chinese
Abstract: Surgical resection remains the cornerstone of therapy for early stage lung cancer. Five-year survival rates are reported as high as 92% for stage Ⅰ non-small cell lung cancer (NSCLC). However, many patients presenting with resectable early stage disease are unable to tolerate pulmonary resection, even sublobular resection, because of compromised cardiopulmonary functions or other comorbidities. Traditionally,patients deemed medically inoperable have been treated by external-beam radiation. But the results were poor with a mean survival of 20 months and a 5-years survival rate of 12%. In this scenario, we need to develop other non-surgical local therapies. One of these was image-guided percutaneous radiofrequency ablation(RFA).Many clinical trials show that RFA for lung tumors is a minimally invasive, feasible and safe technique with minor mortality and morbidity. Moreover, its efficacy seems to be promising, even in the long-term follow-up.Further experiences and comparison with other emerging minimally invasive local treatments are required to determine its rote in the treatment of medically inoperable early stage NSCLC.