Expression of MCM2 and its prognostic significance in patients with non-small cell lung cancer
10.3760/cma.j.issn.1006-9801.2010.01.008
- VernacularTitle:微小染色体维持蛋白2在非小细胞肺癌的表达及其预后意义
- Author:
Yu CHEN
;
Xiuhong NIE
;
Xiuyi ZHI
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
MCM2 protein;
Carcinoma,non-small cell lung;
Prognosis
- From:
Cancer Research and Clinic
2010;22(1):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of MCM2 and its prognostic significance in non-small cell lung cancer (NSCLC). Methods The expression of MCM2 was measured by immunohistochemistry in 73 cases of NSCLC and 10 cases of normal lung tissue. The correlations between the expression of MCM2 and clinic-opathological parameters and prognosis were investigated. Results There was no MCM2 expression in normal lung tissue and positive rate of MCM2 expression was 87.7% in NSCLC. The difference between the two groups was significant (P<0.001). The expression of MCM2 in poorly differentiated NSCLC patients was significantly higher than that in moderately- and well-differentiated NSCLC patients (P=0.008). The expression of MCM2 in patients with squamous carcinoma was higher than that in patients with adenocarcinoma (P=0.005). The hazard ratio was significantly higher(RR=3.389, 95 % CI=1.803-7.146,P<0.001), and the accumulated survival rate was significantly lower (P=0.001) in NSCLC patients with higher MCM2 expression than that of lower expression. MCM2 was independent prognostic factor of NSCLC patients (P=0.041). Conclusion MCM2 could reflect the reproductive activity of NSCLC and has some clinical significance for assessing the development and prognosis of NSCLC. MCM2 was a potential target for future treatment.
