Expression of XIAP mRNA and Survivin mRNA in non-small cell lung cancer and their clinical significance
10.3760/cma.j.issn.1006-9801.2010.01.010
- VernacularTitle:XIAP mRNA和Survivin mRNA在非小细胞肺癌的表达及其临床意义
- Author:
Jinming ZHAO
;
Tiehua RONG
;
Jianhua FU
;
Zhaohong WU
;
Gangdong CHEN
;
Gefei WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Apoptosis;
Reverse transciptase polymeroase chain reacltion;
XIAP;
Survivin
- From:
Cancer Research and Clinic
2010;22(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of the expression of XIAP mRNA and Survivin mRNA in non-small cell lung cancer and their relationship. Methods RT-PCR was used to evaluate the expression of XIAP mRNA and Survivin mRNA in 59 cases of NSCLC and corresponding normal tissues.Results There was a significant difference in XIAP mRNA expression in primary lung and corresponding normal tissues (61.0 % vs 30.5 %, P<0.05), whereas there were no significant correlation between the XIAP mRNA expression and gender, age, smoking history, histological subtype, T stage, lymph node metastatic status and TNM stage. There was a significant difference in Survivin mRNA expression in primary lung and corresponding normal tissues (81.4 % vs 23.7 %, P<0.05), whereas there were no significant correlation between the Survivin mRNA expression and gender, age, smoking history, histological subtype, T stage, lymph node metastatic status and TNM stage. Conclusion The significant difference of XIAP mRNA and Survivin mRNA expression between the tumor and corresponding normal tissues implies they might play important roles in the carcinogenesis and progress of NSCLC and might become marker for the diagnosis and target for treatment of NSCLC.
