Treatment of intractable choledocholithiasis with multiple biliary stent placements:a randomized controlled study
10.3760/cma.j.issn.1007-5232.2010.01.008
- VernacularTitle:多支架植入治疗难治性胆总管结石的随机对照研究
- Author:
Zhijian ZHANG
;
Dazhou LI
;
Wen WANG
;
Kerong LIN
;
Qiaoliang YUE
;
Qiuping WU
;
Xiaodong WEN
- Publication Type:Journal Article
- Keywords:
Choledocholithiasis;
Cholanglopancreatography,endoscopic retrograde;
Stent
- From:
Chinese Journal of Digestive Endoscopy
2010;27(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of different methods of biliary stenting for intractable choledocholithiasis.Methods A total of 137 patients with intractable choledocholithiasis were randomly divided into 4 groups to receive different managements.The treatments included single biliary stent placement in group A (n=32),single stent placement plus oral medication in group B (n=35),double stents placement in group C (n=33) and double stents placements plus oral medication in group D (n=37).All biliary stents were placed via endoscopic retrograde cholangiopancreatography (ERCP).Oral medication included ursodeoxycholic acid and/or anethol trithione after the procedure.All patients were closely followed up.Results The size of stones in common bile duct (CBD) decreased in all cases at 3 months after stent placement,with most significant changes in groups C and D than in groups A and B (P＜0.05).The stents kept unobstructed for a mean time of 7.6 months (3.5-20 months),with a significant difference between every 2 groups (P＜0.05) and a longest duration time in group D.A second procedure of ERCP was performed in 72 patients (52.6%),with achievement of total choledocholithiasis clearance in 51 (84.7%).Hyperamylasemia (HA) occurred in 41 cases (29.9%),which were mainly observed in the groups C and D (P ＜0.05).Conclusion Biliary stent placement is a safe and effective palliative therapy for intractable choledocholithiasis,while double stents placements combined with pharmacotherapy is most effective.
