Relationship between expression of DAS-1 protein in intestinal metaplasia and gastric cardia adenocarcinoma
10.3760/cma.j.issn.0254-1432.2010.01.005
- VernacularTitle:贲门肠上皮化生组织中DAS-1蛋白表达与贲门癌的相关性研究
- Author:
Shuguang HAO
;
Xiaoshan FENG
;
Lidong WANG
;
Shegan GAO
;
Gongping WANG
;
Jiangtao SUN
;
Jianfeng HOU
;
Qiang CHEN
;
Yi RU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Intestinal metaplasia;
DAS-1 protein
- From:
Chinese Journal of Digestion
2010;30(1):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between expression of DAS-1 in gastric cardia intestinal metaplasia(CIM)and gastric cardia adenocarcinoma (GCA). Methods The cancerous tissues and CIM tissues (2 cm apart from caneer) obtained from 65 patients with GCA were examined for the expression of DAS-1 protein using immunohistoehemistry. The CIM tissues (<2 cm below Z line) obtained from 15 outpatients and inflammatory mucosa from 25 outpatients were also examined for expression of DAS-1 protein. Results The type Ⅲ IM was accounted for 55.4% (36/65) in GCA patients, which was significantly higher than that in outpatients [13.3% (2/15), P<0.01]. The positive rate of DAS-1 expression in cancerous tissues [78.5 % (51/65)] was also significantly higher than that in CIM tissues [38.8 %(30/80), P<0.01]. The expression of DAS-1 protein in IM tissues was gradually increased from type Ⅰ (0%) to type Ⅲ (71.1%) with positive correlation (P<0.01). Conclusions The type Ⅲ IM with over-expression of DAS-1 is closely related to GCA, which might be one of important precancerous lesions for GCA.
