Investigation of relationship between the phlegm and adhesion molecule of gastric cancer
10.3760/cma.j.issn.1006-9801.2010.02.007
- VernacularTitle:胃癌痰湿证型与血清中黏附分子相关性的临床研究
- Author:
Xiaodong GUO
;
Tinghui JIANG
;
Gang JIN
;
Xiao WEI
;
Pinkang WEI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Phlegm syndrome;
Intercelluar adhesion molecule;
Neoplasm metastasis
- From:
Cancer Research and Clinic
2010;22(2):92-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe relationship between the phlegm and adhesion molecule and further explore the functions of the phlegm in the metastatic potential of the tumors. Methods Examin the expression difference of ICAM-1,E-cad,MMP-9 of gastric cancer by enzyme linked immunosorbent assay between the phlegm-stamp type and non-phlegm-stamp type,then reducing phlegm by chinese medicine treatment and comparing theirs expression variation.Results The expressions of ICAM-1,E-cad, MMP-9 were obviouslv different between the phlegm group and non-phlegm group[(403.6±99.7)μg/L,(9.08±1.69)mg/L,(465.0±96.64)μg/L &(319.9±81.4)μg/L,(7.56±1.15)mg/L,(228.1±43.79)μg/L].After using xiao-tan-san-jie recipes,the expressions of ICAM-1 and E-cad of the phlegm group were obviously lower than before(P<0.05);the expression of MMP-9 was also falling down,but the difference was not significative.Conclusion There is a correlation between the phlegm and adhesion molecule, which could take action in tumor metastams by affecting adhesion molecule expression.
