Expression and significance of Cathepsin D and Laminin receptors in gastric cancers
10.3760/cma.j.issn.1006-9801.2010.02.011
- VernacularTitle:胃癌组织中组织蛋白酶D和层黏连蛋白受体的表达及意义
- Author:
Xiaoyan XU
;
Yonghong SHI
;
Huiling YU
- Publication Type:Journal Article
- Keywords:
Cathepsin D;
Receptors,laminin;
Stomach neoplasms;
lmmunohistochemistry
- From:
Cancer Research and Clinic
2010;22(2):105-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the elationship between the expression of Cathepsin D and Laminin receptors with the invasion and metastasis of gastric cancers.Methods Cathepsin D and Laminin receptors immunoreactivities were evaluated in 96 patients with gastric cancer using streptavaclin pemxidase method.Results Over expression of Cathepsin D in gastric cancer tissue was significantly related with the depth of invasion,lymphnode metastasis and grade of differentiation (P<0.01,P<0.01 and P<0.05, respectively).Moreover,the high expression of Lamninin receptors in gastric cancer had significant correlations with the invasion depth and grade of differentiation(P<0.05 and P<0.01);The positive expression of Laminin receptors were not significantly related with lymph node metastasis(P>0.05).By statistics analysis Cathepsin D had a significant positive correlation with Laminin receptors (P<0.05). Conclusion Cathepsin D and Laminin Receptors play all important role in the invasion and metastasis of gastric Cancers.
