Expressions and relativity research of Cyclic B1 and Cyclic D1 in severe reflux esophagus, Barrett's esophagus and esophageal adenocarcinoma
10.3760/cma.j.issn.1006-9801.2010.02.013
- VernacularTitle:周期蛋白B1和D1在重度反流性食管炎、Barrett食管和食管腺癌中的表达及相关性研究
- Author:
Lan WANG
;
Jinchun LIU
;
Jingguang LIANG
;
Haifang ZHANG
- Publication Type:Journal Article
- Keywords:
Esophagitis,peptic;
Barrett esophagus;
Esophageal neoplasms;
Adenocarcinoina;
Cyclin B1;
Cyclin D1
- From:
Cancer Research and Clinic
2010;22(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of Cyclin B1 and Cyclin D1 on Barrett esophagus,Barrett's esophagus mixed with atypical dysplasia and esophageal adenocarcinoma.Methods Cyclin B1 and Cyclin D1 were examined with immunohistochemistry.76 esophageal tissues of patients werB collected,including severe reflux esophagitis(RE,25 cases),Barrett esophagus(BE,35 cases),Barrett esophagus mixed with atypical dysplasia(DY,8 cases),esophageal carcinoma(CA,8 cases).Ten cases with normal esophageal mucosa were examined as the control. Results Cyclin B1 and Cyclin D1 were high expression in the specimens of the BE,DY and CA groups and very low expression in the control and RE group.Statistieal difference Was showed(P<0.01).Expression of Cyclin D1 was increasing gradually from the tissues of intestinal metaplasia,atypical dysplasia to adenocarcinoma(50.04 vs 67.94 vs 74.31).There Was significant difference among these three groups(P<0.01).Conclusion Cyclin B1 and Cyclin D1 as markers of tumour development could evaluate the risk from Barrett esophagus to adenocarcinoma.Perhaps it is the earlv event in the development of esophageal carcinoma.
