Hypoxia-inducible factor-1α expression in the collagen induced arthritis model and its significance

VernacularTitle:低氧诱导因子-1α在CIA模型中的表达及其意义
Author: Senzhou CHEN ; Xianfeng WANG ; Qiaoyan HOU ; Wen WANG ; Shasha LI
Publication Type:Journal Article
Keywords: Hypoxia-inducible factor-1α; Rheumatoid arthritis; Ⅱ type collagen induced arthritis
From: Chinese Journal of Microbiology and Immunology 2010;30(2):115-119
CountryChina
Language:Chinese
Abstract: Objective To study the hypoxia-inducible factor-1α (HIF-1α) expression in the col-lagen induced arthritis(CIA) model and its role in rheumatoid arthritis (RA) pathogenesis. Methods We established CIA model, and taked CIA model of the ankle joint to have them HE staining and HIF-1α immu-nohistochemistry staining, then the HIF-1α expression in the tissues of RA was observed. Results The ex-pression of CIA synovial membrane of rat and the lower synodal both was expressed in HIF-1α. The positive expression of HIF-1α reached the highest volume in the first 21 days. Then, with the disease progression, the expression gradually decreased, which was in significantly positive relation with the synovial pathology score, synovial hyperplasia and angingenesis rating score, however, the expression was no positively correla-ted with the inflammatory infiltration. Conclusion The expression of HIF-1α in RA tissue is positively re-lated with inflammation severity, It indicates that HIF-1α is closely related to the occurrence and develop-ment of RA.