Relationship between environmental exposures,genetic polymorphism of NAT2 and colorectal cancer
10.3760/cma.j.issn.1006-9801.2010.02.006
- VernacularTitle:环境暴露、N-乙酰基转移酶-2基因多态性与大肠癌的关系
- Author:
Xiane PENG
;
Yingying JIANG
;
Lin LI
;
Zhimin HUANG
;
Zhijian HU
;
Xishun SHI
- Publication Type:Journal Article
- Keywords:
Intestinal neoplasms;
Acetyhransferases;
Genetic susceptibility;
Geneticpredisposition to disease;
Environmental exposures
- From:
Cancer Research and Clinic
2010;22(2):89-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between NAT2 genetic polymorphism and the risk of colorectal cancer. Methods A hospital-based case-control study was conducted and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect its genotypes.Results The frequency of NAT2 slow genotype was 19.58% in cases with colorectal cancer compared.with increased the risk for developing colorectal cancer and their OR were 2.16(95% CI:1.31～3.54).Conclusion The results suggest that NAT2 genetic polymorphism is associated with colorectal canoer susceptibility.People with NAT2 slow genotype have higher coloreetal cancer risk.
