Mathodological evaluation of reporting of clinical randomized controlled trials In the field of digestive diseases in China
10.3760/cma.j.issn.0254-1432.2010.02.006
- VernacularTitle:国内消化病学领域临床随机对照试验方法学的评价
- Author:
Sun SHI
;
Yu BAI
;
Can XU
;
Xia YANG
;
Ming YANG
;
Duowu ZOU
;
Zhaoshen LI
;
Guoming XU
- Publication Type:Journal Article
- Keywords:
Digestive system disease;
Evidence-based medicine;
Randomized controlled trails;
Evaluation stadies;
Bibliometrics
- From:
Chinese Journal of Digestion
2010;30(2):94-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the current quality of the reporting of randomized controlled trials (RCTs) related to digestive diseases in China. Methods All the papers related to RCTs published in Chinese Journal of Digestion from 1999 to 2008 were hand-searched by professional staff then evaluated and analyzed them according to the international reference standard. ResultsIn the 3298 issues of the recent ten years, there were 92 research papers of RCTs which was accounting for 2.8%. The sample size ranged from 18 to 5241. Sixty-one (66.0%) trials included the exact standard of internalize and exclusion. Sixteen (17.4%) trails told the specific method of random allocation and 22(23.9%) were double-blinded. Fifty-eight (63.0%) trials compared the baseline condition of each groups. Seventy-three(79.3%) trails showed the specific approach of statistic. In the end, only 7(5.7%) trails were identified as the strictly-designed RCTs. Conclusions The quantity and quality of the clinical RCTs can not satisfy the demand of clinical practice. Strictly-scientific designed, multicentered, large sample prospective clinical RCT should be advocated.
