TGF-β change in blister fluid of hypertrophic scar and its significance
10.3760/cma.j.issn.1671-0290.2010.03.016
- VernacularTitle:增生性瘢痕水泡液β转化生长因子的变化及意义
- Author:
Youfu XIE
;
Hui CHEN
;
Qingmei LI
;
Darong LIANG
- Publication Type:Journal Article
- Keywords:
Scar;
Blister;
Cytokine;
Transforming growth factor β
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2010;16(3):195-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate of the tissue TGF-β changes at early stage of hypertrophic scar formation and the value of scar blisters in hypertrophic scar.Methods The TGF-β1 content in the blister fluid and the blood were quantified with ELISA,patients(n=15)with hypertrophy scar after depth burn were included,three time point(each n=5)on early stage(<3 months)of hypertrophy scar formationwere monitored.and normal skin blister fluid and the blood(n=5)was used as control.Results The serum TGF-β1 in the both hypertrophic scar patients and normal skin group was not elevated(P>0.01),the TGF-β1 in the blister of normal skin was also not elevated(P>0.01),but TGF-β1 level in the scarblisters hypertrophic scar was elevated significantly[<60 d(158.5±69.8)pg/L,60-90 d,(181.1±40.1)pg/L,>90 d,(534.4±125.9)pg/L,P<0.01] and higher than the normal skin blister and the blood(P<15.6 pg/L.P<0.01),the increased TGF-β1 1evel in the hypertrophic scar blisters were persisted for at least three months.the TGF-β1 level of scar blister on the 3th month of hypertrophic scar formation reached a peak [(534.4±125.9)pg/L,P<0.01].Conclusions The data in this study indicates that TGF-β production at the early stage of hypertrophic scar formation is increased and may play an important role in scar formation;scar blisters is a valuable approach in hypertrophic scar study.
