Impact of CYP2C19 genetic polymorphism on efficacy of Helicobacter pylori eradication with proton pump inhibitor-based triple therapy
10.3760/cma.j.issn.0254-1432.2010.02.007
- VernacularTitle:细胞色素P450 2C19基因多态性对以质子泵抑制剂为基础的三联疗法根除幽门螺杆菌疗效的影响
- Author:
Yuping QIU
;
Xiaolin PAN
;
Jing MO
;
Rihua ZHANG
;
Fujun ZHAO
;
Qiyun TANG
;
Jinliang NI
;
Guoxin ZHANG
- Publication Type:Journal Article
- Keywords:
Helicobacter pylor;
Proton pump inhibitor;
Levofloxacin;
Cytochrome P450 2C19,human
- From:
Chinese Journal of Digestion
2010;30(2):98-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy of triple therapy including proton pump inhibitor (PPI), levofloxacin and amoxicillin for the first-line treatment of H. pylori infection, and the relation between H. pylori eradication and CYP2C19 genetic polymorphism. Methods Two hundred and five H. pylori-positive patients were divided into group E_(20) (esomeprazole 20 mg twice daily), group E_(40)(esomeprazote 40 mg twice daily),group R (rabeprazole 10 mg twice daily) and group L (lansoprazole 30 mg twice daily). Besides PPI, all patients were received levofloxacin 500 mg daily and amoxicillin 1000 mg twice daily for 1 week. The CYP2C19 genotypes were detected in 161 patients. The eradication of H. pylori were analyzed by intention-to-treat (ITT) and per protocol (PP) methods.ResultsThe H. pylori eradication was 86.70% in group E_(20), 88.5% in group E_(40),73.5% in group R and 78.1% in group L. Whereas the H. pylori eradication was 90% in patients with PM genotype,81.5% in patients with HetEM genotype and 82.1% in patients with HomEM genotype. The H.pylori eradication was 83.4% and 79.00% by per protocol (PP) and intention-to-treat (ITT) analyses,respectively. There was no significant difference in H. pylori eradication among four groups (P>0.05), and no relation was found between H. pylori eradication and genotypes (P>0.05). Conclusions PPI based triple therapy was effective in eradication of H. pylori, which is not influenced by CYP2C19 genotypes.
