Clinical value of confocal laser endomicroscopy in diagnosis of early esophageal squamous cell carcinoma and precancerous lesions
10.3760/cma.j.issn.0254-1432.2010.04.003
- VernacularTitle:共聚焦激光显微内镜对早期食管鳞癌和癌前病变的诊断价值
- Author:
Lijun GAO
;
Tao YU
;
Xiaomeng GU
;
Xiuli ZUO
;
Rui JI
;
Changqing LI
;
Chuanlian CHU
;
Wenbo LI
;
Yanqing LI
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Endomicroscopy,confocal;
Intraepithelial neoplasia
- From:
Chinese Journal of Digestion
2010;30(4):226-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of confocal laser endomieroscopy (CLE) in diagnosis of early esophageal squamous cell carcinoma and precancerous lesions. Methods CLE examination was performed in 41 patients who needed further examination because of lesions in esophagus during July 2008 to April 2009. The diagnosis was made based on the features of esophageal squamous cells which was defined as low grade intraepithelial neoplasia(LGIN), high grade intraepithelial neoplasia (HGIN) and early esophageal squamous cell carcinoma (EC). Biopsy specimens were taken precisely matched to the CLE imaging sites. The result was compared with that of histopathology. Results There were 7281 eonfocal images obtained from 60 target lesions in 41 patients. The sensitivity, specificity and accuracy of CLE were 75.0%, 88.6% and 85.0% in diagnosis of LGIN, respectively, 85.7% ,92.3% and 90.0% in diagnosis of HGIN, respectively,and 88.9% ,96.1% and 95.0%, in diagnosis of EC,respectively. Conclusions It is an effective method for diagnosis of esophageal neoplastic lesions using CLE, which has high accuracy in diagnosis of HGIN and early esophageal cancer.
