Association of serum cytokines with pancreatic function in patients after acute pancreatitis
10.3760/cma.j.issn.0254-1432.2010.04.007
- VernacularTitle:急性胰腺炎后患者血清再生相关细胞因子与胰腺功能的相关性研究
- Author:
Li HUANG
;
Yaping XU
;
Deqing WU
;
Guoyong HU
;
Li CHENG
;
Jiaqing SHEN
;
Xuanfu XU
;
Chuanyong GUO
;
Xingpeng WANG
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
Pancreatic function tests;
Cytokines
- From:
Chinese Journal of Digestion
2010;30(4):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cytokines on pancreatic function in patients after acute pancreatitis(AP) and its mechanisms. Methods Fifty-nine patients (mild in 25 and severe in 34) after AP and 20 healthy controls were enrolled in the study. Serum levels of cytokines including hepatocyte growth factor (HGF), epidermal growth factor(EGF), basic fibroblast growth factor (bFGF), regeneration protein(Reg)-1 and Reg-4 were determined using enzyme-linked immunosorbent assay (ELISA). Fasting blood-glucose, insulin, C-peptide and fecal elastase 1 (FE1) were detected for evluation of endocrine and exocrine pancreatic function. The association of pancreatic function with clinical parameters and serum cytokines was analyzed. Results The expression of FE1 was lower in patients [(205.9±18.3) μg/g] after AP in comparison with the controls [(333.9±19.7) μg/g, P<0. 01], but levels of fasting blood-glucose, C-peptide and insulin were higher in patients group (P<0.01). Serum level of HGF was higher in patients with insufficient pancreatic exoerine [(983.76±372.65) pg/ml] than those with normal exocrine function [(263.44±110. 35) pg/ml]. Meanwhile,EGF level was higher in patients with DM after AP [(704.41±190. 37) pg/ml] than those without DM [(360. 03±48.39) pg/mh P<0.05]. There was a negatively correlation between FE1 and HGF (P ＜0. 01). The abnormal fasting blood glucose was correlated with CT grading (P<0. 05).Conclusions The patients after AP develope insufficient exocrine and endocrine function. Serum EGF and HGF may be associated with restoration of pancreatic endocrine and exocrine function.
