Expression of DDH and VEGF in esophageal carcinoma and their relationship

VernacularTitle:二氢二醇脱氢酶和血管内皮生长因子在食管癌中的表达
Author: Peimin GUO ; Liqun CAO ; Bingbing YU
Publication Type:Journal Article
Keywords: Vascular endothelial growth factors; Esophageal neoplasms; Dihydrodiol dehydrogenase
From: Cancer Research and Clinic 2010;22(5):326-328
CountryChina
Language:Chinese
Abstract: Objective To study the expression of DDH and VEGF in esophageal carcinoma and their relationship, and their prognostic significance for patients of esophageal carcinoma.Methods The expression of DDH and VEGF in 61 esophageal carcinoma tissues and border areas were detected by immunohistochemistry SABC method.Results The positive rate of DDH and VEGF in esophageal carcinoma tissues are higher than those in border areas,both of their expression were correlated with TNM stages,grades of cell differentiation and lymph node metastasis.Patients expressing DDH and VEGF seemed to have a poor prognosis.The expression of DDH was found in a positive correlation with VEGF. Conclusion DDH and VEGF were correlated with the tumorigenesis and progression of esophageal carcinoma patients.