Study on the CD8+T lymphocyte non-cytotoxic antivirus response in the slow progressors of HIV infected individuals

VernacularTitle:HIV-1感染疾病缓慢进展者CD8+T淋巴细胞非细胞毒性免疫应答作用的研究
Author: Ying PAN ; Wenqing GENG ; Hualu CUI ; Yongjun JIANG ; Hong SHANG
Publication Type:Journal Article
Keywords: CD8+T lymphocyte non-cytotoxic antivirus response(CNAR); HIV
From: Chinese Journal of Microbiology and Immunology 2010;30(5):456-459
CountryChina
Language:Chinese
Abstract: Objective To investigate the change of CD8+T lymphocyte non-cytotoxic antivirus response(CNAR)in slow progressors infected by HIV.Methods Applying with density gradient and immunomagnetic beads methods to purify the CD4+T lymphocyte from the healthy person and CD8+T lymphocyte from HIV-infected individuals.The CD4+T cell was infected by HIV(SF-33)virus and cocuhured with CD8+T cell.The culture supernatant was collected and the p24 value was detected by ELISA method.Results Our study showed that the CNAR function decreased by turns of slow progressors(SP),typical progressors(TP),health control group and AIDS group.There was significant difference between groups(P<0.01).We found a significant positive correlation between the CIM+T cell ture count and the CNAR function.The virus load didn't statistically correlate with the CNAR function.Conclusion The CNAR function possibly protected the HIV-infected individuals from progression.