The expression of galectin-3 and osteopontin in esophageal carcinoma

VernacularTitle:半乳糖凝集素-3及骨桥蛋白在食管癌中的表达及其意义
Author: Xiangwen WU ; Hui LI ; Bin HU ; Jinbai MIAO ; Xingyuan JIA
Publication Type:Journal Article
Keywords: Galectin-3; Osteopontin; Esophageal neoplasms; Micrometastasis
From: Cancer Research and Clinic 2010;22(5):300-302
CountryChina
Language:Chinese
Abstract: Objective To investigate the galectin-3 (Gal-3) and osteopontin (OPN) expression in esophageal carcinoma and analyze its clinical significance.Methods Thirty-seven patients who suffered from esophageal carcinoma were selected from 2006 to 2008.There were 28 males and 9 females,aged from 41 to 82 vears old.The levels of Gal-3 mRNA and OPN mRNA in tissues were detected by Fluorescent PCR,and the levels of Gal-3 and OPN in blood plasma were measured by ELISA.Result The expression of Gal-3 mRNA and OPN mRNA were significantly different between the esophageal carcinoma,side of carcinoma and normal esophagus tissues (F=11.934,F=4.269,P<0.05);The expression of galectin-3 and osteopontin were correlated with pathological grading (F=3.216,P