Transcranial magnetic stimulation and the expression of Bcl-2 and brain derived neurotrophic factor after cerebral infarction
10.3760/cma.j.issn.0254-1424.2010.04.002
- VernacularTitle:不同时间窗经颅磁刺激对脑梗死大鼠Bcl-2及脑源性神经营养因子表达的影响
- Author:
Man LI
;
Mengdie WANG
;
Yanling SONG
;
Yuanwu MEI
;
Gang LI
;
Yuan FANG
- Publication Type:Journal Article
- Keywords:
Transcranial magnetic stimulation;
Cerebral infarct;
B-cell lymphoma/leukemia-2 gene;
Brain derived neurotrophic factors
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2010;32(4):245-248
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of transcranial magnetic stimulation (TMS) on the rehabilitation of rats with cerebral infarction. Methods One hundred Sprague-Dawley rats were randomly divided into a normal group, a sham-operated control group, a model group and a TMS group with 25 rats in each group. A cerebral infarction model was established in the latter two groups by left middle cerebral artery occlusion (MCAO). TMS was started at either 12 or 24 hours after reperfusion, and sham-TMS was given to the first two groups at the same time points. The expression of Bcl-2 mRNA and BDNF mRNA were measured by RT-PCR after 14 days. Results Bcl-2 mRNA and BDNF mRNA were detected in all groups. The expression of Bcl-2 mRNA in the TMS-12 h group, and that of BDNF mRNA in the TMS-24 h group were significantly higher than in the other groups. Conclusions The expression of Bcl-2 mRNA and BDNF mRNA in the brains of rats after cerebral infarction peak when TMS is administered 12 h and 24 h after reperfusion, respectively. TMS might have protective and rehabilitative effects on rats after cere-bral infarct.
