Effect of serum uric acid on clinicopathology and prognosis of IgA nephropathy

VernacularTitle:血清尿酸对IgA肾病临床病理及预后的影响
Author: Genyang CHENG ; Dongwei LIU ; Zhangsuo LIU
Publication Type:Journal Article
Keywords: Uric acid; Glomerulonephritis,IgA; Pathology,clinical; Prognosis
From: Chinese Journal of Nephrology 2010;26(5):343-345
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of serum uric acid (SUA) on the clinicopathological manifestation and prognosis of IgA nephropathy(IgAN)patients. Methods A total of 348 patients with renal biopsy-proven IgAN in our hospital were enrolled in this study.The data were retrospectively analyzed to examine the association of SUA level with clinicopathological manifestation and prognosis of IgA nephropathy(IgAN)patients. Results There were no significant differences of 24 hour proteinuria,BUN and Scr between patients of high SUA level with various GFR and those of normal SUA level.While differences of glomerular sclerosis,tubulointerstitial scores and vascular injury between these two groups were significant (P＜0.05).At the end of follow-up,prevalence of GFR decline and ESRD was significantly higher in patients with high SUA as compared to those with normal SUA(40.82%vs 15.70%,64.71% vs 35.00%,respectively,P＜0.05). Conclusions Patients with different SUA levels have similar clinical manifestations,but different pathological findings and prognosis.It is important to pay attention to the follow-up of SUA level in IgAN patients.