Study on the relationship between cyclin D1 G870A polymorphism and gastric cancer
- VernacularTitle:细胞周期素D1基因多态性与胃癌关系的研究
- Author:
Ai JIA
;
Jun GONG
;
Yingchao LI
;
Zhiming HAO
;
Xinming CHANG
;
Lei DONG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Cyclin D1;
Gene polymorphism;
Helicobacter pylori
- From:
Chinese Journal of Digestion
2008;28(10):690-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess whether the G870A polymorphism of cyclin D1 (CCND1)was associated with individual susceptibility to gastric cancer in China. Methods Case-control study of 214 individuals was conducted, including 108 controls (non ulcerative dyspepsia) and 106 cases of gastric cancer. The polymorphism analysis of CCND1 A/G was performed in blood samples by PCR-RFLP method. Results The frequency of GG genotype was 19.8% and 7.4% in patients with gastric cancer and controls, respectively. The risk for gastric cancer in patients homozygous (GG) for CCND1 genotypes was 3.5 times higher in comparison with patients carrying AA genotypes (P＜0.05, OR =0.281). Furthermore, the stratification analyses showed that the male, elderly (≥60 years) or H. pylori infected gastric cancer patients who carrying GG genotype were more susceptible to gastric cancer compared with those carrying AA or GA genotype. Conclusion GG genotype is associated with increased susceptibility to gastric cancer in high risk area of Xi'an.
