Efficacy and Mechanism of Action of Saireito Therapy for Autoimmune Recurrent Abortion Indexed by Antinuclear Antibody and Anticardioripine Antibody
10.3937/kampomed.59.699
- Author:
Takashi KANO
;
Yasuyo HIJIKATA
;
Masahiko SHIMIZU
;
Kayoko KAWADA
;
Kumi HIGASA
;
Takahisa USHIROYAMA
- Publication Type:Journal Article
- Keywords:
recurrent spontaneous abortion;
autoimmune disorder;
saireito;
antinuclear antibody;
antiphospholipine antibody
- MeSH:
Therapeutic procedure;
Unspecified Abortion;
Antinuclear Antibody Assay;
Antibodies;
Immunoglobulin M measurement
- From:Kampo Medicine
2008;59(5):699-705
- CountryJapan
- Language:Japanese
-
Abstract:
The efficacy of Saireito (a herbal preparation) against autoimmune recurrent abortion was evaluated clinically and immunologically. Saireito therapy was performed with 87 women having experienced 3 or more recurrent abortions in the early stages of pregnancy (less than 12 weeks gestation), and whose antinuclear antibody (ANA) and anti-cardiolipine antibody (ACA) test results were positive. The effects of this therapy on the percentage of women in whom abortion was successfully prevented (the abortion prevention rate), and on the antibody titer were investigated. Among the 49 women who became pregnant during the study period, the abortion prevention rate was 63.3%, the percentage of ANA positive cases was 65.6%(32/49), the percentage of ACA IgG and/or IgM positive cases (as evaluated by SRL methods) was 65.5%(29/49) and the percentage of both ANA and ACA IgG and /or IgM positive cases was 75.0%(12/49). Although the titer of ANA was not significantly reduced by this therapy, the titer of ACA IgM was reduced significantly.These results suggest that Saireito exerts its efficacy by suppressing humoral immunity through its adjustment of the Th1/Th 2 cytokine balance. This therapy is expected to be effective against ACA-positive recurrent abortion by reducing the effects of ACA. Furthermore, in 2 observed child birth cases whose ACA titer were not decreased by Saireito, different effective mechanisms were speculated; for example, suppression of platelet aggregation via saireito's component herbs (ninjin and bukuryou) similar to the effect seen with low-dose aspirin therapy, or its “risui” effect via its components (bukuryou, soujyutu, takusha and chorei).
