Is Tokishakuyakusan Clinically Useful in Treatment of Immunologic Recurrent Abortion?
10.3937/kampomed.59.273
- Author:
Takashi KANO
;
Yasuyo HIJIKATA
;
Masahiko SHIMIZU
;
Kayoko KAWADA
;
Kumi HIGASA
;
Takahisa USHIROYAMA
- Publication Type:Journal Article
- Keywords:
tokishakuyakusan;
recurrent abortion;
autoimmune disorder;
alloimmune disorder;
saireito
- MeSH:
Unspecified Abortion;
immunologic;
tokishakuyakusan;
Therapeutic procedure;
Pregnancy Trimester, First
- From:Kampo Medicine
2008;59(2):273-277
- CountryJapan
- Language:Japanese
-
Abstract:
Clinical efficacy of tokishakuyakusan against immunologic recurrent abortion was evaluated using methods of diagnostic statistics. The subjects of this study were 38 women with recurrent abortion who had experienced a spontaneous abortion during their first trimester (within 12 weeks of pregnancy) twice, and who took tokishakuyakusan (extract granules) after development of their third pregnancy, but experienced spontaneous abortion again during their first trimester, with the karyotype of the aborted fetus being rated as 46, XX or 46, XY. The control group consisted of 244 women who had experienced 3 or more spontaneous abortions during their first trimester of pregnancy. The detection rates of autoimmune disorders and alloimmune disorders were compared statistically between the two groups. Neither the detection rate of autoimmune recurrent abortion nor the detection rate of alloimmune recurrent abortion differed significantly between the two groups, suggesting that tokishakuyakusan is not clinically effective against immunologic recurrent abortion. Tokishakuyakusan is estimated to prevent abortion caused by compromised luteal insufficiency of the uterus. Thus, saireito seems to provide a more rational means of Kampo therapy for immunologic recurrent abortion.
