Students always have many questions and problems during active participation. Here, we report an active learning course (AL) based on problems that medical students encountered in gross anatomy practice. This AL was implemented after the practice, consisting of a lecture, group discussions, resource hours, and presentation session to ensure exploratory learning. Based on a questionnaire survey, 75.1% of the students evaluated the AL as very valuable or valuable, indicating its usefulness. The AL not only complemented the anatomy course, but also directed the students toward other forms of basic and clinical learning. The results indicate that by making use of gross anatomy practice, the AL functions as a hub for horizontal and vertical integrations in medical education.