T-cell Responses to Dengue Virus in Humans
10.2149/tmh.2011-S09
- Author:
Ichiro Kurane
;
Takaji Matsutani
;
Ryuji Suzuki
;
Tomohiko Takasaki
;
Siripen Kalayanarooj
;
Sharone Green
;
Alan L. Rothman
;
Francis A. Ennis
- Publication Type:Journal Article
- Keywords:
Dengue virus;
T-cell response;
T-cell receptor;
Dengue fever;
Dengue hemorrhagic fever
- From:Tropical Medicine and Health
2011;39(4SUPPLEMENT):S45-S51
- CountryJapan
- Language:English
-
Abstract:
Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. These highly activated T cells are DENV-specific and oligoclonal. Multiple kinds of lymphokines are produced by the activated T cells, and it has been hypothesized that these lymphokines are responsible for induction of plasma leakage, one of the most characteristic features of DHF. Thus, T-cells play important roles in the pathogenesis of DHF and in the recovery from DENV infection.