The Association of Cytokines with Severe Dengue in Children
10.2149/tmh.2014-09
- Author:
Julia N.A. Mangione
;
Nguyen Tien Huy
;
Nguyen Thi Phuong Lan
;
Evaristus Chibunna Mbanefo
;
Tran Thi Ngoc Ha
;
Lam Quoc Bao
;
Cao Thi Phi Nga
;
Vo Van Tuong
;
Tran Van Dat
;
Tran Thi Thuy
;
Ha Manh Tuan
;
Vu Thi Que Huong
;
Kenji Hirayama
- Publication Type:Journal Article
- Keywords:
Association;
cytokine;
dengue;
severity;
shock
- From:Tropical Medicine and Health
2014;():-
- CountryJapan
- Language:English
-
Abstract:
Background: Dengue virus infection is a major public health problem. A hypothesis put forward for severe dengue is the cytokine storm, a sudden increase in cytokines that induces vascular permeability. Previous studies and our recent meta-analysis showed that IL-6, IL-8, IFNγ, TNFα, VEGF-A and VCAM-1 are associated with dengue shock syndrome. Therefore, in this study we aim to validate the association of these cytokines with severe dengue. Methods & Findings: In a hospital based case control study in Vietnam, children with dengue fever, other febrile illness and healthy controls were recruited. Dengue virus infection was confirmed by several diagnostic tests. Multiplex Immunoassay using Luminex technology was used to measure cytokines simultaneously. A positive association with dengue shock syndrome was found for VCAM-1, whereas a negative association was found for IFNγ. Furthermore, the multivariate logistic analysis also showed that VCAM-1 and IFNγ were independently correlated with dengue shock syndrome. Conclusion: IFNγ and VCAM-1 were associated with dengue shock syndrome, although their role in the severe dengue pathogenesis remains unclear. Additional studies are required to further investigate the function of these cytokines in severe dengue.
