Safety Evaluation of Methoxyflavones Mixture (Ⅱ) from Kempferia parviflora：28-day Repeated Dose Oral Toxicity Test
10.1625/jcam.14.33
- VernacularTitle:黒ショウガ由来メトキシフラボン混合物(Ⅱ)の安全性評価：マウスによる28日間反復経口投与毒性試験
- Author:
Hirotaka OHKUWA-HAYASHI
;
Takanori FUJITA
;
Takuya KAWATA
;
Yoshihisa NAKANO
;
Tomihisa OHTA
- Keywords:
Kaempferia parviflora;
methoxyflavone;
28-day repeated dose oral toxicity test
- From:Japanese Journal of Complementary and Alternative Medicine
2017;14(1):33-37
- CountryJapan
- Language:Japanese
-
Abstract:
Kaempferia parviflora rhizome is used folk medicines for treatment of various symptoms in Thailand since anticent times.Several types of methoxyflavones has been identified in this plant and their physiological functions have been reported.We determined that six kinds of methoxyflavones (5,7,3',4'-tetramethoxyflavone, 3,5,7,3',4'-pentamethoxyflavone, 5,7-dimethoxyflavone, 5,7,4'-trimethoxyflavone, 3,5,7-trimethoxyflavone, 3,5,7,4'-tetramethoxyflavone) were included in the 80% ethanol extract of K. parviflora rhizome.The safety of six methoxyflavones mixture was evaluated with 28-day repeated oral dose toxicity test in mice.These results indicated no significant toxicity on body weight, blood analyses, organ weight, blood biochemical analyses.
