Search for Oral Medicine That Might Exacerbate the Prognosis of Adverse Drug Events in Elderly Patients
10.11256/jjdi.18.277
- VernacularTitle:高齢者において有害事象の予後が悪化する可能性のある 内用医薬品の探索
- Author:
Yoshihiro Noguchi
;
Yuta Hayashi
;
Aki Yoshida
;
Ikuto Sugita
;
Hiroki Esaki
;
Kousuke Saito
;
Kazumasa Usui
;
Misa Kato
;
Tomoya Tachi
;
Hitomi Teramachi
- Publication Type:Journal Article
- Keywords:
Japanese Adverse Drug Event Report database;
the elderly patients;
risk ratio
- From:Japanese Journal of Drug Informatics
2017;18(4):277-283
- CountryJapan
- Language:English
-
Abstract:
Objective: Elderly patients commonly experience adverse drug events (ADEs) owing to their poor drug metabolizing and excretion ability, and these often cause multiple organ dysfunction syndrome. Therefore, it is important that we identify the adverse drug events early on during prognosis. We searched for oral medicines that might exacerbate the prognosis of ADEs in elderly patients.
Methods: The objects under analysis were oral medicines that were registered in the Japanese Adverse Drug Event Report database (JADER). The associations between the elderly/non-elderly patients and exacerbation risk/non-exacerbation risk were analyzed by risk ratios (RR). The signal detection of exacerbation risk was defined as 95% confidence interval of lower limit of risk ratio>1 and χ2≥4.
Results: The oral medicines that might markedly exacerbate the prognosis of ADEs in the elderly patients in comparison with the ADEs of young patients included 84 items, of which 63 have not been described as potentially inappropriate medicines in all guidelines for medical treatment of the elderly patients.
Conclusion: In this study, while we could not search for oral medicines having a high risk of ADEs, we were able to search for oral medicines that might exacerbate the prognosis of ADEs in elderly patients. This result could contribute to the proper use of medicines in the elderly patients.
