Achievement of Insulin Reduction and Rapid Stabilization of Blood Sugar by Administering Insulin and GLP-1 Receptor Agonist in Type 2 Diabetes
10.2185/jjrm.65.273
- VernacularTitle:インスリンとGLP 1受容体作動薬の併用で，インスリン減量と早期の血糖平坦化の達成を実現できたと考えられCGMで確認できた１例
- Author:
Shota KAKOI
;
Toshinori NIMURA
;
Takao SAKAI
;
Akihiro NISHIZAKI
;
Taketo SUZUKI
;
Shuji YAMADA
;
Kazutoshi MURASE
;
Hajime TANAKA
;
Shigehiro TOMIMOTO
;
Yoshitsugu TAKAHASHI
;
Tadahisa MIYAMOTO
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
2016;65(2):273-278
- CountryJapan
- Language:Japanese
-
Abstract:
A 63-year-old woman was admitted with complaints of thirst and polyuria about 1 year after ceasing therapy in November, X and in October, X+1. Her blood glucose levels at the beginning of her admissions were 347 at the first admission and 486 at the second admission. We administered glargine, a long-acting type insulin, 8U/day, and a short-acting insulin, glulisine, 4U/day, during the first admission. We administered glargine, a long-acting type insulin, 4U/day, and a short-acting insulin, glulisine, 3U/day, during the second admission. We also administered a GLP-1 receptor agonist, liraglutide, 0.3mg/day. Blood glucose levels (mg/dl) during the 5 days of the first admission were as follows: first, -, -, 347, and 180; second, 273, 266, 109, and 188; third, 75, 192, 186, and 182; fourth, 93, 194, 91, and 144; fifth, 78, 95, 124, and 127. In the second admission, blood glucose levels were as follows: first, -, -, 486, and 299; second: 140, 137, 195, and 128; third: 101, 122, 114, and 108; fourth: 101, 123, 123, and 137; and fifth, 89, 136, 111, and 129. CGM data showed an average of 128mg/dl and standard deviation of 34 during the first admission. CGM data showed an average of 125mg/dl and standard deviation of 20 during the second admission. The reduction of insulin and rapid flattening of blood sugar were achieved by GLP-1 receptor agonist with promotion of insulin secretion and suppression of glucagon secretion.
