Inhibitory Effects of Watercress on Tumor Promotion in a Mouse Model of Two-stage Skin Carcinogenesis
10.1625/jcam.13.1
- VernacularTitle:クレソンのマウス二段階皮膚発癌実験における腫瘍発現の抑制効果
- Author:
Ken YASUKAWA
;
Hiroshi KANNO
;
Susumu KITANAKA
;
Yoshiko YANAGIMOTO
- Publication Type:Journal Article
- Keywords:
watercress;
Nasturtium officinale;
antitumor promotion;
two-stage carcinogenesis;
cancer prevention;
sitosterol 3-O-glucopyranoside
- From:Japanese Journal of Complementary and Alternative Medicine
2016;13(1):1-6
- CountryJapan
- Language:English
-
Abstract:
Cancer prevention is one of the most urgent problems in the field of public health worldwide. The methanol extract of watercress ( Nasturtium officinale) inhibits 12-O-tetradecaonoylphorbol-13-acetate (TPA)-induced ear edema in mice. The extract also exhibits marked antitumor activity in in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[α]anthracene as an initiator and TPA as a promoter. From the active fraction of the methanol extract, sitosterol 3-O-glucopyranoside (1) was isolated and identified. This compound was evaluated for its inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice, and had a 50% inhibitory dose of 299 nmol/ear. These results indicate that watercress extracts are useful in cancer prevention.
