Effects of Radon Inhalation on Blood Counts, and Blood Chemistry in Rats

VernacularTitle:ラドン吸入によるラットの血液像及び血液生化学的変化
Author: Hidehiko MURAYAMA ; Kazuyo NEGISHI ; Kohji SAKAMOTO
Publication Type:Journal Article
From:The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 1981;45(2):18-23
CountryJapan
Language:Japanese
Abstract: Recently bathing with low concentration radon inhalations become popular in Japan.
However, a few experimental studies have been done on the effect of the radon inhalations. In this study, effect of sublethal dose inhalations of radon on rats were examined. Sprague-Dawley male young rats were exposed to the radon in arerage concentration of 1.43μCi/l daily 6-7hrs for the successive 6-7 days.
Immediately after the last inhalation the distribution of daughter nuclides of radon in various organs were determined. Specific activity of the lung, kidney, spleen liver, small intestine and testis were 41.4, 25.4, 3.47, 3.16, 9.30, and 1.36nCi/g tissue respectively.
20hrs. after the inhalation white blood cell count, red blood cell count, hemoglobin content, serum cholesterol, triglyceride total protein, albumin, total bilirubin, glucose contents and enzyme activities of ALP, GOT, GPT and LDH were determined. Cholesterol content of the inhalation group was higher than that of the control group significantly (P<0.02). In other parameters, there were no significant difference between the inhalation and the control groups.