Heterogeneous susceptibility of Helicobacter pylori isolated from a single biopsy in adults and children to metronidazole and clarithomycin
- Author:
Nguyen Van Bang
- Publication Type:Journal Article
- Keywords:
Antimicrobial resistance;
Helicobacter pylori;
Heterogeneity
- MeSH:
Helicobacter pylori, Adult, Child, Metronidazole
- From:Journal of Medical Research
2005;38(5):23-27
- CountryViet Nam
- Language:Vietnamese
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Abstract:
Growing increase in resistance of H. pylori strains to antibiotics of choice is identified worldwide, requiring further investigating susceptible characteristics of the germ to these agents. Objectives: To assess the resistance of H. pylori individual colonies from a single biopsy to metronidazole and clarithromycin. Methods: The E - test was used to determine the Minimum Inhibitory Concentrations (MICs) of these two antimicrobial drugs for ten H. pylori colonies isolated from an initial gastric biopsy culture from each of 14 adults and 14 children. Results: Among patients haboring HP strains resistant to these 2 antimicrobials, we observed heterogeneity in metronidazole resistance in 14/22 cases and in clarithromycin resistance in 3/13 cases. The number of resistant individual colonies ranged from 2/10 to 9/10 depending on subjects. Conclusions: In the same biopsy from both adults and children different colonies of H. pylori displayed different antimicrobial susceptibility patterns prior to anti - H. pylori treatment, rendering antibiogram interpretation difficult.
