Effects of Moxibustion on Phagocytic Activity in Mice (report 4)
10.3777/jjsam.33.238
- VernacularTitle:マウス貪食能に及ぼす施灸刺激の影響 (第4報)
- Author:
Eiji FURUYA
;
Masako OKAZAKI
;
Koji SAKAMOTO
- Publication Type:Journal Article
- From:Journal of the Japan Society of Acupuncture and Moxibustion
1984;33(3):238-245
- CountryJapan
- Language:Japanese
-
Abstract:
Effects of moxibustion on liver injury induced by CCl4 and ethionine in mice were investigated in the reticuloendothelial system. The phagocytic activity was determined by the carbon clearance method and the activity of lysosomal enzyme (acid phosphatase and β-glucuronidase) in peritoneal exudate cells was measured.
Male ddY and ICR mice (5 weeks old) were used as experimental animals.
Liver injury was produced by the administration of carbon tetrachloride (CCl4) in a dose of 0.04ml/body in olive oil, p. o., or single administration of ethionine in a dose 1g/kg, i. p.
15mg of moxa was divided into 6 cones and they were treated by each 3 cones on right and left LV-14.
We obtained the following results. After 15 times administration of CCl4 (3 times a week), the rise of serum transaminase (GOT, GPT), the decrease of K index and α index which meant phagocytic activity and the increase in liver/body (L/B) and spleen/body (S/B) weight ratio were recognized. For CCl4 induced liver injury, α index and S/B weight ratio were improved by 10 times moxibustion (2 times a week). After 15 times moxibustion (3 times a week), the tendency to increase in K index and to decrease of α index was seen and, at the same time, an increase in L/B weight ratio was seen.
On the other hand, an increase in K index was induced after single administration of ethionine and simultaneous single moxibustion showed the tendency to decrease of K index.
It was suggested that moxibustion play an important role to regulate the mechanism of reticuloendothelial system on CCl4 or ethionine induced liver injury.
