Cardiodynamics and Infarct Size in Regional and Global Ischemic Isolated Heart Model: Comparison of 1 Hour and 2 Hours Reperfusion.
10.4070/kcj.2012.42.9.600
- Author:
June Hong KIM
1
;
Jun KIM
;
Yong Hyun PARK
;
Kook Jin CHUN
;
Jeong Su KIM
;
Young Ho JANG
;
Mi Young LEE
;
Zhelong XU
Author Information
1. Institute of Cardiovascular Research Center, Pusan National University Yangsan Hospital, Yangsan, Korea. weonjo@pnuyh.co.kr
- Publication Type:Original Article
- Keywords:
Heart;
Myocardial ischemia;
Myocardial infarction;
Myocardial reperfusion
- MeSH:
Animals;
Heart;
Ischemia;
Myocardial Infarction;
Myocardial Ischemia;
Myocardial Reperfusion;
Rats;
Reperfusion;
Salicylamides
- From:Korean Circulation Journal
2012;42(9):600-605
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: We investigated whether 1 hour reperfusion is enough to assess cardiodynamics and infarct size in both regional ischemia (RI) and global ischemia (GI) in isolated rat heart models. MATERIALS AND METHODS: Hearts were randomly assigned to one of the following groups (each n=14): 1) Sham hearts for 1 hour; 2) Sham hearts for 2 hours; 3) 30 minutes RI followed by 1 hour reperfusion; 4) 30 minutes of RI followed by 2 hours reperfusion; 5) 30 minutes GI followed by 1 hour reperfusion; and 6) 30 minutes GI followed by 2 hours reperfusion. RESULTS: There were no significant differences in infarct size between 1 hour and 2 hours reperfusion in both RI and GI. Left ventricular developed pressure was significantly decreased at both 1 hour and 2 hours reperfusion in groups of RI and GI compared to baseline (p<0.01). Rate-pressure product and +dP/dtmax also significantly decreased compared to baseline level at both 1 hour and 2 hours reperfusion in groups of RI and GI (p<0.05). CONCLUSION: There was no significant difference in infarct size between 1 hour and 2 hours reperfusion in groups of RI and GI. Cardiodynamic variables measured at 1 hour and 2 hours reperfusion significantly decreased compared to baseline level. Our data suggests that reperfusion of 1 hour is sufficient to assess cardiodynamics in both regional and global ischemic isolated hearts model.
