The rate of p53 gene carrier in the high risk group of exposure to dioxine
- Author:
Bach Khanh Hoa
- Publication Type:Journal Article
- Keywords:
Gene p53;
Gene mutations;
Exposure;
Dioxine;
High risk
- MeSH:
Genes, p53
- From:Journal of Medical Research
2005;38(5):15-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Diseases caused by dioxine include mainly various types of cancers and p53 is one important gene in carcinogenesis-suppressing gene family. Objectives: This research's goal is detecting p53 gene's ratio in the high risk group of exposure to dioxine. Methods: In this study we detected p53 ratio in 50 cases in the group of high risk of exposure to dioxine and the control group of 30 cases. Gene p53 was detected by PCR technique. Results: The study showed that in the control group (no exposure to dioxine), p53 prevalence is 100% compared with 82% in high - risk group (p <0.05). Conclusions: p53 was not detected in 18% of the group of high risk exposure to dioxin, suggesting that there were serious damages in p53 gene (deletion...)
