Delayed Neuro-Toxicity of Organophosphorous Agents As Demonstrated by Use of Hens
10.2185/jjrm.33.190
- VernacularTitle:ニワトリを用いた有機燐剤の遅発性神経毒性に関する実験的研究
- Author:
Eishiro Abe
;
Kiichiro Sasaki
;
Kazuo Kurosawa
;
Shinji Asanuma
;
Akira Suzuki
;
Shosui Matsushima
;
Kazuhiro Kawahara
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1984;33(2):190-197
- CountryJapan
- Language:Japanese
-
Abstract:
To demonstrate delayed neuro-toxicity of organophosphate, we administered 13 types of organophosphorous pesticide to hens. Initially, a screening test was performed with nine varieties of the chemical product. Later, four types were given to the fowls. Those hens dosed with S-Seven and Surecide developed ataxia and other neurophatic symptoms in the lower limbs.
After 50 days of observation, all the hens were killed and anatomized. Phathohistological examination revealed various changes in the hens that developed neuropathic symptoms: atrophy, diminution and disappearance of nerve cells in the anterior horn of the spinal cord ; edematous changes in the myelin; swelling of the neuroglia ; atrophy and vaculolar degeneration of liver cells; and necrobiosis of nepaticlobures.
It was found that these changes are closely related with the development of ataxia and doses of the chemical.
It was also found that the pathotistological changes occurred to a less extent in those hens which did not develop toxicoses.
