Efficacy of the use of adsorbents in the treatment of paraquat poisoning of dog
10.2185/jjrm.30.791
- VernacularTitle:Paraquat中毒に対する吸着剤の効果に関する研究
- Author:
Masakazu Kawai
;
Masahide Koyama
;
Yoshihiro Kaneko
;
Sadanori Ogasawara
- Publication Type:Journal Article
- From:Journal of the Japanese Association of Rural Medicine
1981;30(4):791-802
- CountryJapan
- Language:Japanese
-
Abstract:
While there are not any effective antidotes for paraquat poisoning up to this time, several procedures such as gastric lavage, dosing of emetics and adsorbents, hemodialysis, peritoneal dialysis and hemoperfusion have been applied in treatment of paraquat intoxication.
In this study, we determined efficacy of the combined application of oral administration of an adsorbent (Adsorbin) and hemoperfusion using activated charcoal (HEMOSORBA: activated charcoal coated collodion, The ASAHI Medical Co.) in dogs being given orally paraquat in the amount of 40 mg per kg of the body weight.
Efficacy of the treatments was in order of the combined application of dosing Adsorbin and the hemoperfusion with Hemosorba, single use of dosing Adsorbin and single application of the hemoperfusion.
Oral administration of the adsorbent was carried out only once, either one hour or three hours after forced dosing of paraquat, and the hemoperfusion was started either one or three hours after paraquat dosing and continued for six hours in each case.
Effectiveness of the treatment on the survival-time was superior in the case of dosing the adsorbent and starting the hemoperfusion one hour after paraquat administration.
As a sign of developing lung fibrosis was found on histopathological observation in dogs survived for twenty days after starting the experiment, even in case of the combined treatment with the best results, observation of longer period seems to be necessary for obtaining more information after treatment. And it is furthermore advisable that the treatment, especially the hemoperfusion, should be continued or carried out more than one time until the concentration of paraquat in blood plasma decreases to the safe level.
