A Randomized Human Study on the Safety and Effectiveness of Powdered Food of Agaricus blazei Murill
10.1625/jcam.12.95
- VernacularTitle:アガリクス (Agaricus blazei Murill ) 粉末食品の安全性と有効性に関するランダム化ヒト試験
- Author:
Kazuo UEBABA
;
Hoko KYO
;
Nobutaka SUZUKI
;
Teturo URATA
- Publication Type:Journal Article
- Keywords:
Agaricus, NK activity, IFN-γ, TGF-β, IL-12, High-sensitivity CRP, QOL
- From:Japanese Journal of Complementary and Alternative Medicine
2015;12(2):95-101
- CountryJapan
- Language:Japanese
-
Abstract:
Safety and effectiveness of powered food made from Agaricus blazei Murill was evaluated by a randomized human study. 45 healthy subjects were divided into 3 groups in sequence: control, 1 pack and 3 packs/day-administered groups. Each group had 15 persons. They had each packs for 28 days, and followed, in every two weeks, by the evaluation with CTCAE v3.0, QOL (SF36-v2), and biochemical examinations including liver/lung/kidney function, insulin resistance and NK activity and high-sensitivity CRP. None of them had adverse events nor biochemical/lung abnormal examinations. 1 and 3 packs-administered groups improved their QOL, high-sensitivity CRP and NK activity in a dose-dependent manner. These results ascertained safety, and effectiveness of the powdered food made from Agaricus blazei Murill against presymptomatic disorders including metabolic syndrome.
