Effects of fibrin glue on bone formation in combination with deproteinized bone xenografts in humans.
- Author:
Moon Su KIM
1
;
Su Gwan KIM
;
Sung Chul LIM
;
Hak Kyun KIM
;
Seong Young MOON
Author Information
1. Department of Oral & Maxillofacial Surgery, College of Dentistry, Chosun University, Korea. sgckim@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
Fibrin glue;
Bone formation;
Deproteinized bone xenografts
- MeSH:
Absorption;
Biocompatible Materials;
Bone and Bones;
Bone Regeneration;
Fibrin;
Fibrin Tissue Adhesive;
Floors and Floorcoverings;
Humans;
Maxilla;
Minerals;
Osteogenesis;
Transplantation, Heterologous;
Transplants
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2008;34(1):19-27
- CountryRepublic of Korea
- Language:English
-
Abstract:
Thirty-six sinus grafts were performed in 34 patients with an alveolar crest bone height in the posterior maxilla of 3 to 5 mm before grafting. The sinuses were grafted using Bio-Oss alone or mixed with fibrin glue. Group 1 was the control group and included 25 patients who received a xenograft mixed in saline. Group 2 comprised 9 patients who received a xenograft and fibrin glue. The study was further subdivided at the time of 9 months. This histologic study evaluated by hematoxylin-eosin (H & E) and histomorphometric analysis whether fibrin glue in combination with Bio-Oss enhances bone regeneration in sinus floor elevation in humans. The new bone formation was better in Group 2 than in Group 1, but the difference was not significant. The absorption of the graft material was faster in Group 2 than in Group 1, in the short term, but better in Group 1 over the long term, although the difference was not significant. Lamellar bone was formed earlier in Group 1 compared to Group 2, but the difference was not significant. Overall, the surgery site stabilized earlier with new bone formation in Group 2 than in Group 1, but the difference was not significant. Combining a fibrin sealant and Bio-Oss could lead to improved scaffolds for bone tissue engineering based on the synergistic effects of the biomaterials. Therefore, Bio-Oss or Bio-Oss plus Tisseel may be used depending on the situation.
