Three Asymptomatic Cases of Suspected Drug-Induced Liver Injury Possibly Caused by Scutellariae Radix
10.3937/kampomed.66.212
- VernacularTitle:黄芩による薬物性肝障害が疑われた3例
- Author:
Tetsuro OIKAWA
;
Yukari GONO
;
Tomoaki FUKUDA
;
Tomoe HORIKAWA
;
Hiromitsu HOTTA
;
Yukiko MORI
;
Tadaaki KAWANABE
;
Tatsuya ISHIGE
;
Hiroshi ODAGUCHI
;
Akino WAKASUGI
;
Toshiyuki OKUTOMI
;
Toshihiko HANAWA
- Publication Type:Journal Article
- Keywords:
drug-induced liver injury;
Scutellariae Radix orengedokuto;
saikokeishikankyoto;
bofutsushosan
- From:Kampo Medicine
2015;66(3):212-217
- CountryJapan
- Language:Japanese
-
Abstract:
Case reports of drug-induced liver injury caused by Kampo medicines are on the rise, but most of them are noted for related symptoms such as jaundice. Usually, severe liver injury is detected by chance upon routine medical checkup. Recently, we noted 3 cases of suspected drug-induced liver injury caused by orengedokuto, saikokeishikankyoto and bofutsushosan. In these 3 cases, maximum ALT was under 100 IU/l and no symptoms related to liver injury were observed. Early detection by blood test was useful, and appropriate treatment quickly improved and normalized the abnormal values associated with liver injury. We should always be alert for drug-induced liver injury caused by Kampo medicines, especially when prescribing formulations that include Scutellariae Radix. We also emphasize the importance of scheduling blood tests when prescribing these formulations.
