Comparative Analysis of Growth Patterns in Colorectal Cancers that Invaded to.
- Author:
Dae Hoon LIM
1
;
Seo Gue YOON
;
Kyong Woo CHOI
;
Hee Jin CHANG
Author Information
1. Department of General Surgery, National Medical center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Colorectal Neoplasms
- MeSH:
Colon;
Colorectal Neoplasms*;
Fibrosis;
Follow-Up Studies;
Humans;
Incidence;
Inflammation;
Lymph Nodes;
Lymphatic Metastasis;
Rectum;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Society of Coloproctology
1997;13(3):333-342
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In this retrospective study, 49 patients who were treated by surgical resection of colorectal cancer, confuted to proper muscle and confirmed histologically from 1979 to 1996 were included. To examine the significance of growth pattern in terms of polypoid growth(PG)(n=26; m,sm 5, pm 21) and non-polypoid growth(NPG)(n=23; m,sm 3, pm 20), we analyzed several clinocopathologic variables by x2 test and unpaired t-test, 5-year survival rate by Kaplan-Meier method and Log-Rank statistics according to growth type comparatively: 1) In the PG tumor, muscle elevation(P<0.0117) and association with adenoma(P<0.0001) were more frequent than in the NPG. 2) The NPG type showed smaller size(P<0.0172) and higher rate of lymph node metastasis(P=0.025) and higher tendency of lymphatic invasion(P=0.07) and poor differentiation(P=0.0693) and deeper invasion(P=0.0972) and worse 5-year survival(P=0.0607). 3) Otherwise there was no difference in inflammation, fibrosis, and angioinvasion. 4) The mean thickness of Outer Longitudinal Muscle(OLM) was thicker in rectum than colon(rectum 1.62 mm, colon 0.74 mm, p<0.0059) and pm cancer was more in rectum than in colon(rectum 10.3%, colon 4.0% , p=0.0057). In the view of results, NPG in early colorectal cancer may suggest the possibility of de novo cancer. NPG type was smaller in the size but more aggressive in lymph node metastasis, lymphatic invasion, invasion depth, tumor differentiation, 5-year survival rate. So it needs more thorough follow up. The higher incidence of pm cancer in rectum than in colon, is probably due to thicker OLM of rectum than that of colon.
