Protective Effect of Polyphenol on Cytotoxicity of 24S-Hydroxycholesterol on the Brain-Derived Cells
10.1625/jcam.9.65
- VernacularTitle:24S-ヒドロキシコレステロールの細胞毒性に対するポリフェノールの保護効果
- Author:
Eri HASEGAWA
;
Saori NAKAGAWA
;
Kaori TAKAHASHI
;
Susumu YAMATO
- Publication Type:Journal Article
- Keywords:
24S-Hydroxycholesterol;
Polyphenol;
Cytotoxicity
- From:Japanese Journal of Complementary and Alternative Medicine
2012;9(1):65-68
- CountryJapan
- Language:Japanese
-
Abstract:
The protection to the cytotoxicity of 24S-hydroxycholesterol on the brain-derived cells should be useful as a new therapy of Alzheimer’s disease. In this study, we have revealed neuroprotective effect of polyphenol, especially (−)-epigallocatechin-3-gallate and (−)-epicatechin gallate on cytotoxicity of 24S-hydroxycholesterol. These results suggest the possibility of a new complementary therapy for Alzheimer’s disease.
