Safety Evaluation of Fucoidan from Kjellmaniella Crassiforia and Extract from Hypsizigus Marmoreus: Influence on the Activities and Gene Expressions of Rat Hepatic CYPs
10.1625/jcam.9.1
- VernacularTitle:ガゴメ昆布フコイダンときのこテルペンエキスの安全性評価：ラット薬物代謝酵素への影響
- Author:
Hiromu OHNOGI
;
Yoko KUDO
;
Shoko HAYAMI
;
Yuko TAKIMOTO
;
Riho SUZUKI
;
Nobutaka SUZUKI
- Publication Type:Journal Article
- Keywords:
Gagome kombu fucoidan;
Kinoko terpene extract;
safety;
drug-metabolizing enzyme;
CYP
- From:Japanese Journal of Complementary and Alternative Medicine
2012;9(1):1-7
- CountryJapan
- Language:Japanese
-
Abstract:
Object: Gagome kombu (Kjellmaniella cracciforia) is the edible brown seaweed and contains fucoidan, a sulfated polysaccharide, abundantly. Bunashimeji (Hypsizigus marmoreus) is the popular Japanese mushrooms and contains polyterpenes as the bitter substance. Previously, we investigated the bioactive functions (e.g. anti-tumor action) and the safety of fucoidan from Gagome kombu (GKF) and the extract from Bunashimeji (KTE: Kinoko terpene extract). In this study, we evaluate the influence of GKF and KTE on hepatic cytochrome P450 (CYP).
Methods: Male SD rats were divided into three groups (n = 5). 2,000 mg/kg of GKF and KTE were given orally once daily for 4 days.
Result: There were no difference in activities and mRNA expressions of hepatic CYPs (CYP2C11, CYP2D, CYP2E1 and CYP3A1) among all groups.
Conclusion: These results indicated GKF and KTE did not influence the rat hepatic CYPs.
