Safety Evaluation of Fucoidan from Kjellmaniella Crassifolia in Genotoxicity Tests
10.1625/jcam.8.61
- VernacularTitle:ガゴメ昆布（Ｋｊｅｌｌｍａｎｉｅｌｌａ ｃｒａｓｓｉｆｏｌｉａ）由来フコイダンの遺伝毒性試験による安全性の評価
- Author:
Hiromu OHNOGI
;
Yuko TAKIMOTO
;
Riho SUZUKI
;
Jeffry M STRONG
;
Nobutaka SUZUKI
- Publication Type:Journal Article
- Keywords:
fucoidan;
Gagome kombu;
safety;
genotoxicity test
- From:Japanese Journal of Complementary and Alternative Medicine
2011;8(2):61-65
- CountryJapan
- Language:Japanese
-
Abstract:
We evaluated the safety of fucoidan from Gagome Kombu (GKF) in genotoxicity tests. In bacterial reverse mutation test, GKF had no reverse mutation inducing activity on five bacterial strains with or without S9 metabolic activation. In chromosome aberration test, GKF had neither structural nor numerical chromosome aberration inducibility with or without S9 metabolic activation. In micronucleus test, neither formation of micronuclei nor decrease of mironucleated reticulocytes was observed in the bone marrow of the mice treated by GKF. These results indicate that GKF has no genotoxic activities under the condition of this study.
