Limited Role of Bone Marrow Aspiration and Biopsy in the Initial Staging Work-up of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma in Korea.
- Author:
Byung Hoon MIN
1
;
Jun Young PARK
;
Eun Ran KIM
;
Yang Won MIN
;
Jun Haeng LEE
;
Poong Lyul RHEE
;
Jong Chul RHEE
;
Jae J KIM
Author Information
- Publication Type:Original Article
- Keywords: Lymphoma, B-cell, marginal zone; Stomach; Bone marrow; Staging
- MeSH: Abdomen; Adult; Aged; Bone Marrow/*pathology; Bone Marrow Examination; Cohort Studies; Female; Helicobacter Infections/*complications; Humans; Lymph Nodes/*radiography; Lymphoma, B-Cell, Marginal Zone/complications/*pathology; Male; Mediastinum/radiography; Middle Aged; Neoplasm Staging; Radiography, Abdominal; Republic of Korea; Retrospective Studies; Stomach Neoplasms/complications/*pathology; Tomography, X-Ray Computed
- From:Gut and Liver 2014;8(6):637-642
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The aim of this study was to investigate the frequency of disseminated gastric mucosa-associated lymphoid tissue (MALT) lymphoma and the role of bone marrow study in the initial staging work-up. METHODS: A total of 194 patients with gastric MALT lymphoma was enrolled. The incidence of disseminated disease was evaluated in the initial staging work-up. The demographic data and tumor characteristics were compared according to Helicobacter pylori infection status. RESULTS: Localized disease of Lugano stage I accounted for 97.4% of the enrolled cases. Abdominal computed tomography revealed abdominal lymph node metastasis in five patients (2.6%). Bone marrow (BM) involvement was found in only one patient without H. pylori infection (0.5%). No patient showed positive findings on chest computed tomography or positron emission tomography. H. pylori-negative cases showed a significantly higher frequency of advanced-stage disease than H. pylori-positive cases (10.0% vs 0.6%). In patients achieving complete remission, no extragastric recurrence occurred during follow-up. CONCLUSIONS: The incidence of disseminated disease, including BM involvement, was very low in Korean gastric MALT lymphoma patients. It might be beneficial to perform BM aspiration and biopsy as a part of staging work-up only in patients with risk factors for advanced disease such as H. pylori negativity.