Predicting Interactions between Medicinal Drugs and New Supplements
10.1625/jcam.7.67
- VernacularTitle:新規サプリメントと医薬品の相互作用を予見する
- Author:
takahiro kubota
;
shin’ichi yoshioka
;
nobuhide kawagoe
;
tsuyoshi toyoda
;
norihito ishibashi
;
nobutaka suzuki
- Publication Type:Journal Article
- Keywords:
adverse effects;
health food products;
supplements;
drug-supplement interactions;
cytochrome P450;
CYP
- From:Japanese Journal of Complementary and Alternative Medicine
2010;7(2):67-74
- CountryJapan
- Language:Japanese
-
Abstract:
Information regarding drug interactions is useful for avoiding adverse effects from medicinal drug administration, and similar information is obviously desirable for health food products and supplements. When examining findings related to drug-supplement interactions, it is vital to understand pharmacokinetics such as drug absorption, distribution, metabolism, and excretion. The interaction disposition of one particular drug is primarily related to inhibition and induction of the drug-metabolizing enzyme cytochrome P450 (CYP). Thus, experiments evaluating the expression level of CYP isoforms in human hepatic microsomes and their relative ratio in drugs metabolized by them would be useful. However, investigations of drug-supplement interactions such as inhibition tests using the cDNA-expressed human CYP and specific substrates in combination are scarce. It is essential to consider studies for averting such interactions and to disseminate information for improving safety.
