28-day Repeated Dose Oral Toxicity Test of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats
- Author:
Hirotaka HAYASHI
;
Takanari ARAI
;
Jeffry M. STRONG
;
Harukuni TOKUDA
;
Yasuko SHIMANO
;
Yasuyuki OHTA
;
Toshiki ENOMOTO
;
Kazuo UEBABA
;
Tomihisa OHTA
;
Nobutaka SUZUKI
- Publication Type:Journal Article
- Keywords: Coix lacryma-jobi L. var.ma-yuen Stapf; Coix seed; safety test; subacute toxicity test; rat
- From:Japanese Journal of Complementary and Alternative Medicine 2009;6(3):131-135
- CountryJapan
- Language:English
-
Abstract:
Coix lacryma-jobi L. var.ma-yuen Stapf (coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of coix seed has rarely been evaluated. We performed a 28-day repeated dose oral toxicity test of hot water extract of all parts of Coix seed in rats. The extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.