The Safety of Excessive Intake of the Food Containing Extract of Cultured Lentinula edodes Mycelia (L.E.M.) in Healthy Adult Volunteers
10.1625/jcam.6.9
- VernacularTitle:健常成人におけるシイタケ菌糸体抽出物 （Ｌ．Ｅ．Ｍ．） 配合食品過剰摂取時の安全性
- Author:
Yasuko YOSHIOKA
;
Makoto TAMESADA
;
Ariaki NAGAYAMA
- Publication Type:Journal Article
- Keywords:
extract of cultured Lentinula edodes mycelia;
L.E.M.;
safety;
excessive intake
- From:Japanese Journal of Complementary and Alternative Medicine
2009;6(1):9-15
- CountryJapan
- Language:Japanese
-
Abstract:
Objective: In this study, we evaluated the safety of excessive intake of granular foods containing extract of cultured Lentinula edodes mycelia (L.E.M.) in healthy adult volunteers.
Methods: Eleven subjects (8 males and 3 females, ages 33.4 ± 9.4) consumed the test foods containing 5,400 mg L.E.M. a day, three times the recommended daily intake, for 4 weeks.
Results: No adverse effect by excessive intake of test foods was observed in physical and clinical exam. No severe symptom was observed, except for mild gastrointestinal symptom such as soft stool in a subject who has hypersensitive intestine.
Conclusion: These results suggest that the granular food containing L.E.M. is safe in healthy adults, even if excessive amount up to 5,400 mg a day is consumed.
