The Inhibitory Effect of Taheebo Extract on Histamine Release from Rat Peritoneal Mast Cells
10.1625/jcam.5.241
- VernacularTitle:南米産樹木茶タヒボ抽出物のヒスタミン遊離抑制作用
- Author:
Norihiro OHTSUBO
- Publication Type:Journal Article
- Keywords:
Tabebuia Avellanedae;
Taheebo;
Mast cells;
Histamine release
- From:Japanese Journal of Complementary and Alternative Medicine
2008;5(3):241-246
- CountryJapan
- Language:Japanese
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Abstract:
The effect of hot water extract of Tabebuia avellanedae (Taheebo) in rat peritoneal mast cells during stimulation of histamine release was studied. Taheebo at concentrations of over 5 μg/ml caused an decrease in histamine release stimulated by C48/80 in a dosage-dependent manner. In the Ca2+ free medium, Taheebo caused a decrease in histamine release too. The effect of Taheebo was suppressed by high concentrations of C48/40 competitively. Taheebo at concentrations of over 10 μg/ml caused an decrease in histamine release stimulated by concanavalin A in a dosage-dependent manner, but the inhibition was non-competitive. These results suggested that Taheebo caused a decrease in the histamine release, which led to a decrease in the allergy symptoms.
